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Formal Name: naphthalen-1-yl(1-(3-(oxiran-2-yl)propyl)-1H-indol-3-yl)methanone

CAS Number: 2365471-31-2

Molecular Formula: C24H21NO2

Formula Weight: 355.4

Purity: ?98%

Formulation: A solution in methanol

Solubility: DMF: 10 mg/ml

DMSO: 10 mg/ml

Ethanol: 10 mg/ml

Methanol: 30 mg/ml

?max: 218, 246, 314 nm

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JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends. 2,3,4 JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.


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The term SC covers all synthetic substances binding to, and agonizing, one of the two known cannabinoid receptors (CB1 or CB2) and their structural/chemical analogues. Colloquially referred to as 'K2' or 'Spice', SCs include a wide range of compounds with various chemical modifications [20]. Given the variety of compounds, there have been difficulties establishing consistent nomenclature in the identification of SCs [37]. Additionally, many naming systems for SCs are employed ranging from those created for marketing purposes (such as 'Black Mamba') to chemical names (typically employed by chemists and forensicists) to colloquial or "street" terms (such as 'K2'). Simplified approaches of creating serial names (such as identifiers based on those that first discover the compound) or systematic abbreviated names have been proposed, but no single naming system has been agreed upon by experts


Most of the compounds have been identified in ready-to-smoke products, but some have occurred only as pure substances in powder form. Pure substances are typically offered as 'research chemicals' and are often available in larger quantities (up to kg amounts) [42].


In pure form, most of the compounds are white crystalline powders. Melting points range from 55??C to 145??C (5-fluoro-AKB48: 55??C, AKB48: 64??C, UR-144: 68??C, XLR-11: 73??C, 5-chloro-UR-144: 79??C, JWH-019: 90??C, 5-bromo-UR-144: 93??C, AM-2201: 94??C, JWH-073: 99.8??C, A796,260: 135??C, STS-135: 139??C, AM-1248: 143??C, AM2233: 145??C). The 'Scientific Working Group for the Analysis of Seized Drugs' (SWGDRUG) is a group consisting of forensic science experts from the USA, England, Canada, Australia, Japan, Germany and the Netherlands [43].

 

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JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist[3] at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5? the affinity at CB2.[4] The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.


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JWH 073 (Item No. 10904) is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2 when tested in rats.2. This product is intended for forensic and research applications.



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Formal Name: [2-methyl-1-(1-methylhexyl)-1H-indol-3-yl]-1-naphthalenyl-methanone

CAS Number:155471-13-9

Molecular Formula: C27H29NO

Formula Weight: 383.5

Purity: ?98%

Formulation: A solution in methanol

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JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist[3] at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5? the affinity at CB2.[4] The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.


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Formal Name: [1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number: 103610-04-4
Molecular Formula: C25H24N2O2
Formula Weight: 384.5
Purity: ?98%
Formulation: (Request formulation change)
A crystalline solid: Solubility
Acetonitrile: 14 mg/ml
DMF: 25 mg/ml
DMF:PBS (pH 7.2) (1:6): 0.1 mg/ml
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?max: 219, 314 nm
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AM2201 (Item No. 10707) is an analytical reference material characterized as a synthetic cannabinoid.1 AM2201 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.
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Product Citations
Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).
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