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JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends. 2,3,4 JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.

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JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist[3] at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5× the affinity at CB2.[4] The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.

On 20 April 2009, JWH-073 was claimed by researchers at the University of Freiburg to have been found in a "fertiliser" product called "Forest Humus", along with another synthetic cannabinoid (C8)-CP 47,497.[5] These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound JWH-073 instead.

JWH 073 (Item No. 10904) is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2 when tested in rats.2. This product is intended for forensic and research applications.

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α-Pyrrolidinopentiophenone (α-PVP) is an analog of the psychoactive stimulant pyrovalerone. α-PVP metabolite 1 is an analog of α-PVP in which the keto group is reduced. The biological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.

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Promethazine (Item No. 22450) is an analytical reference material categorized as a phenothiazine.1 Promethazine has been associated with misuse in conjunction with opioids or sedatives.1,2 Formulations containing promethazine have been used in the treatment of various allergy-related conditions, anesthesia- or surgery-related nausea and vomiting, and to induce sedation. This product is intended for analytical forensic applications. This product is also available as a general research tool (Item No. 16478).

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Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet.

Drink plenty of liquids to help avoid constipation.

Your doctor will tell you how much medicine to use. Do not use more than directed.

Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

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